Fusion toxin protein inhibits CMV infection
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چکیده
منابع مشابه
CMV Infection in CMV-Seropositive Kidney Transplant Recipients
Cytomegalovirus (CMV) infection is a major cause of morbidity in kidney transplant recipients. CMV seropositivity is common in the general population, with a reported prevalence ranging from 30 to 97% (Paya, 2001; Preiksaitis et al., 2005). After primary infection, CMV establishes life-long latency. During the past 2 decades, major advances in the management of CMV infection of transplant patie...
متن کاملCMV infection of transplant recipients.
C YTOMEGALOVIRUS (CMV) LlSUdly CiXlSeS ZiSyIllptOmatic or clinically insignificant infection in the immunocompetent host. Thereafter, the virus persists in a latent state, but may be reactivated by immunosuppression. Reactivation of latent infection most commonly occurs in the context of Human Immunodeficiency Virus (HIV) infection and allogeneic organ transplantation, but has also been describ...
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Background: Some resources have suggested that genetically inactivated pertussis toxoid (PTs) bear a more protective effect than chemically inactivated products. This study aimed to produce new version of PT, by cloning an inactive pertussis toxin S1 subunit (PTS1) in a fusion form with N-terminal half of the listeriolysin O (LLO) pore-forming toxin. Methods: Deposited pdb structure file of the...
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BACKGROUND The first step in infection by human parainfluenza viruses (HPIVs) is binding to the surface of respiratory epithelial cells via interaction between viral receptor-binding molecules and sialic acid-containing receptors. DAS181, a recombinant sialidase protein containing the catalytic domain of Actinomyces viscosus sialidase, removes cell surface sialic acid, and we proposed that it w...
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BACKGROUND The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV), HIV-1, and certain alphaviruses and filoviruses. ZAP binds to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. The common features of ZAP-responsive RNA sequences remain...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4700